Fraunhofer Institute for Cell Therapy and Immunology, Branch Bioanalytics and Bioprocesses IZI-BB
Fraunhofer Institute for Cell Therapy and Immunology, Branch Bioanalytics and Bioprocesses IZI-BB

Dr. Harald Peter

Head of the ivD platform working group

 

© Fraunhofer IZI-BB, Pierre Tangermann

Scientific focus and expertise:

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Harald Peter - ORCID: 0000-0002-3956-6373
  • Peter, H., Mattig, E., Guest, P.C., Bier, F.F. (2022). Lab-on-a-Chip Immunoassay for Prediction of Severe COVID-19 Disease. In: Guest, P.C. (eds) Multiplex Biomarker Techniques. Methods in Molecular Biology, vol 2511. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2395-4_17
  • Mattig, E., Guest, P.C., Peter, H. (2022). A Rapid User-Friendly Lab-on-a-Chip Microarray Platform for Detection of SARS-CoV-2 Variants. In: Guest, P.C. (eds) Multiplex Biomarker Techniques. Methods in Molecular Biology, vol 2511. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2395-4_9
  • Jnana, A., Muthuraman, V., Varghese, V.K., Chakrabarty, S., Murali, T.S., Ramachandra, L., Shenoy, K.R., Rodrigues, G.S., Dendukuri, D., Morschhauser, A., Nestler, J., Peter, H., Bier, F.F., Satyamoorthy, K. (2020). Microbial Community Distribution and Core Microbiome in Successive Wound Grades of Individuals with Diabetic Foot Ulcers. Applied and Environmental Microbiology 2020-03-02 86(6). https://doi.org/10.1128/AEM.02608-19
  • Hays, J.P., Mitsakakis, K., Luz, S., van Belkum, A., Becker, K., van den Bruel, A., Harbarth, S., Rex, J.H., Simonsen, G.S., Werner G., Di Gregory, V., Lüdke, G., van Staa, T., Moran-Gilad, J., Bachmann, T.T., on behalf of the JPIAMR AMR-RDT consortium, The successful uptake and sustainability of rapid infectious disease and antimicrobial resistance point-of-care testing requires a complex ‘mix-and-match’ implementation package. European Journal of Clinical Microbiology & Infectious Diseases volume 38, pages 1015–1022 (2019). https://doi.org/10.1007/s10096-019-03492-4
  • van Belkum A, Bachmann TT, Luedke G, Lisby G, Kahlmeter G, Mohess A, Becker K, Hays JP, Woodford N, Mitsakakis K, Moran-Gilad J, Vila J, Peter H, Rex J, Dunne WM & the JPIAMR AMR-RDT Working Group on Antimicrobial Resistance and Rapid Diagnostic Testing, Developmental roadmap for antimicrobial susceptibility testing systems, Nature Reviews Microbiology, 17, 51–62 (2019). https://doi.org/10.1038/s41579-018-0098-9
  • Nestler, J., Peter, H., Bier, F.F. (2018). Biophotonics, Optik&Photonik. Towards a Fully Integrated Lab-On-A-Chip. Volume13, Issue1, February 2018, Pages 28-31, https://doi.org/10.1002/opph.201800004
  • Peter, H. et al. (2018). Lab-on-a-Chip Device for Rapid Measurement of Vitamin D Levels. In: Guest, P. (eds) Investigations of Early Nutrition Effects on Long-Term Health. Methods in Molecular Biology, vol 1735. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7614-0_35
  • Soria, J., Acera, A., Merayo-LLoves, J., Durán, J.A., González, N., Rodriguez, S., Bistolas, N., Schumacher, S., Bier, F.F., Peter, H., Stöcklein, W. & Suárez, T. Tear proteome analysis in ocular surface diseases using label-free LC-MS/MS and multiplexed-microarray biomarker validation. Sci Rep 7, 17478 (2017). https://doi.org/10.1038/s41598-017-17536-2
  • Peter, H., Wienke, J., Guest, P.C., Bistolas, N., Bier, F.F. (2017). Lab-on-a-Chip Proteomic Assays for Psychiatric Disorders. In: Guest, P. (eds) Proteomic Methods in Neuropsychiatric Research. Advances in Experimental Medicine and Biology(), vol 974. Springer, Cham. https://doi.org/10.1007/978-3-319-52479-5_33
  • Peter, H., Wienke, J., Bier, F.F. (2017). Lab-on-a-Chip Multiplex Assays. In: Guest, P.C. (eds) Multiplex Biomarker Techniques. Methods in Molecular Biology, vol 1546. Humana, New York, NY. https://doi.org/10.1007/978-1-4939-6730-8_25.
  • Kersting S, Rausch V, Bier FF, von Nickisch-Rosenegk M. Multiplex isothermal solid-phase recombinase polymerase amplification for the specific and fast DNA-based detection of three bacterial pathogens. Mikrochim Acta. 2014; 181(13-14):1715-1723. https://doi.org/10.1007/s00604-014-1198-5. Epub 2014 Feb 18. PMID: 25253912; PMCID: PMC4167443.
  • Kersting, S., Rausch, V., Bier, F.F. et al. Rapid detection of Plasmodium falciparum with isothermal recombinase polymerase amplification and lateral flow analysis. Malar J 13, 99 (2014). https://doi.org/10.1186/1475-2875-13-99.
  • Kozma P, Kehl F, Ehrentreich-Förster E, Stamm C, Bier FF. Integrated planar optical waveguide interferometer biosensors: a comparative review. Biosens Bioelectron. 2014 Aug 15;58:287-307. https://doi.org/10.1016/j.bios.2014.02.049. Epub 2014 Feb 28. PMID: 24658026.
  • Scheller FW, Yarman A, Bachmann T, Hirsch T, Kubick S, Renneberg R, Schumacher S, Wollenberger U, Teller C, Bier FF. Future of biosensors: a personal view. Adv Biochem Eng Biotechnol. 2014; 140:1-28. https://doi.org/10.1007/10_2013_251. PMID: 24196315.
  • Pierce KE, Peter H, Bachmann TT, Volpe C, Mistry R, Rice JE, Wangh LJ. Rapid detection of TEM-type extended-spectrum β-lactamase (ESBL) mutations using lights-on/lights-off probes with single-stranded DNA amplification. J Mol Diagn. 2013 May;15(3):291-8. https://doi.org/10.1016/j.jmoldx.2013.02.002. Epub 2013 Mar 19. PMID: 23518216.
  • Schumacher S, Lüdecke C, Ehrentreich-Förster E, Bier FF. Platform technologies for molecular diagnostics near the patient's bedside. Adv Biochem Eng Biotechnol. 2013; 133:75-87. https://doi.org/10.1007/10_2012_165. PMID: 23192590.
  • Kozma P, Lehmann A, Wunderlich K, Michel D, Schumacher S, Ehrentreich-Förster E, Bier FF. A novel handheld fluorescent microarray reader for point-of-care diagnostic. Biosens Bioelectron. 2013 Sep 15; 47:415-20. https://doi.org/10.1016/j.bios.2013.03.043. Epub 2013 Mar 29. PMID: 23612063.
  • Peter H, Berggrav K, Thomas P, Pfeifer Y, Witte W, Templeton K, Bachmann TT. Direct detection and genotyping of Klebsiella pneumoniae carbapenemases from urine by use of a new DNA microarray test. J Clin Microbiol. 2012 Dec;50(12):3990-8. https://doi.org/10.1128/JCM.00990-12. Epub 2012 Oct 3. PMID: 23035190; PMCID: PMC3502996.
  • Bier FF, Schumacher S. Integration in bioanalysis: technologies for point-of-care testing. Adv Biochem Eng Biotechnol. 2013; 133:1-14. https://doi.org/10.1007/10_2012_164. PMID: 23344629.
  • Schumacher S, Sartorius D, Ehrentreich-Förster E, Bier FF. Miniaturization for Point-of-Care Analysis: Platform Technology for Almost Every Biomedical Assay. EJIFCC. 2012 Oct 12; 23(3):70-5. PMID: 27683418; PMCID: PMC4975254. http://www.ncbi.nlm.nih.gov/pmc/articles/pmc4975254/
  • Schumacher S, Nestler J, Otto T, Wegener M, Ehrentreich-Förster E, Michel D, Wunderlich K, Palzer S, Sohn K, Weber A, Burgard M, Grzesiak A, Teichert A, Brandenburg A, Koger B, Albers J, Nebling E, Bier FF. Highly-integrated lab-on-chip system for point-of-care multiparameter analysis. Lab Chip. 2012 Feb 7;12(3):464-73. https://doi.org/10.1039/C1LC20693A. Epub 2011 Oct 28. PMID: 22038328.
  • Reiss E, Hölzel R, Bier FF. Preparation of DNA nanostructures with repetitive binding motifs by rolling circle amplification. Methods Mol Biol. 2011;749:151-68. https://doi.org/10.1007/978-1-61779-142-0_11. PMID: 21674371.
  • Zhao X, Nothwehr S, Lara-Lemus R, Zhang BY, Peter H, Arvan P. Dominant-negative behavior of mammalian Vps35 in yeast requires a conserved PRLYL motif involved in retromer assembly. Traffic. 2007 Dec;8(12):1829-1840. https://doi.org/10.1111%2Fj.1600-0854.2007.00658.x. Epub 2007 Oct 17. PMID: 17916227; PMCID: PMC2532708.
  • Restrepo R, Zhao X, Peter H, Zhang BY, Arvan P, Nothwehr SF. Structural features of vps35p involved in interaction with other subunits of the retromer complex. Traffic. 2007 Dec;8(12):1841-1853. https://doi.org/10.1111%2FJ.1600-0854.2007.00659.X. Epub 2007 Oct 17. PMID: 17892535; PMCID: PMC2504507.

  • Assay development for serological assays
  • Assay development for blood, urine, saliva samples and other media
  • Multiplex assays for up to 500 analytes
  • DNA-based assays (microarray)
  • PCR and RT-PCR development
  • Antibody assays
  • Dispensing of diverse biological samples in different volumes/viscosities
  • Coupling of DNA, RNA, proteins and peptides to modified surfaces, (glass, gold, silicon, polymer substrates etc.)
  • Aptamers for in vitro diagnostics
  • Biomolecular interaction analysis, kinetic analysis
  • Kinetic ranking of interactions using Biacore-Flex-chip (peptide-antibody, protein-DNA etc.)
  • Characterization and validation of antibodies (cross-reactivity, specificity)
  • Serum screening
  • Aptamer assays
  • Assay development for biochips, microarray-based assays
  • Feasibility studies for alternative detection systems